Review of Current Evidence for PRP and PRF in Oral Surgery: A Literature Review

The aim of this paper is to provide an updated literature review on the use of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in oral surgery based on the available scientific evidence. A literature search was conducted using four electronic databases (PubMed, Cochrane Library, Scopus, and Web of Science), and clinical studies, randomized controlled trials, meta-analyses, and systematic reviews were evaluated. The biological mechanisms, clinical effectiveness, and practical implications of PRP and PRF were analyzed, with emphasis on their ability to enhance bone and soft tissue regeneration and reduce postoperative morbidity. Based on the findings of this review, PRF emerges as a biologically more durable, easily applicable, and clinically justified adjunct in most oral surgical procedures. PRP serves as a strong early biostimulator, although its effects tend to be shorter lasting. Evidence indicates that both PRP and PRF provide beneficial outcomes in various surgical interventions, including dental extractions, bone regeneration, sinus floor elevation, implantology, and medication-related osteonecrosis of the jaws. In some cases, the best outcomes are achieved through the combined application of PRP/PRF with bone grafts, particularly in regenerative procedures.