Authors: Mladenovski Marko, Popovska Mirjana, Aleksovska Dushica, Petrovski Mihajlo, Bexheti Zendeli Lindita, Spasovski Spiro, Gjorgovska Spasovska Ana, Stojmenova Toneva Verica

DOI: To be acquired

Keywords: Oral mucositis, cannabis oil, radiotherapy, head and neck malignancies

ABSTRACT

Aim: To monitor and perceive the effect of Cannabis Oli (Kanoil) on patient`s pain who were treated with radiotherapy because of malignancies on the head and neck.
Materials and methods: There were 25 patients with malignancies of the head and neck hospitalized at the Clinic for Radiotherapy and Oncology in Skopje. All the patients underwent radiotherapy with daily dose of 2 Gy for the period of 6-7 weeks, regardless their age and gender. Lesions in their mouth were treated with Cannabis Oil 7% CBD (700 mg CBD / 10 ml) whose manufacturer is Replek, Skopje, Republic of North Macedonia. The Visual analogue scale (VAS) was used to assess the pain. In this scale, the intensity of the pain, is determined through numerical values from 0-10 where 0 means no pain, and 10 for the hardest pain. The intensity of the pain is determined in three stages: at zero time, day 10 and 1 month after application of Cannabis Oil.
Results: After 10 days and 1 month treatment with Kanoil it is noticed that the pain intensity is slowly going down. The lowest intensity of pain is noticed after 1 month of treatment. Comparing the results, a significant difference was noticed between the controlled and the examined party (p≤0,001).
Conclusion: Kanoil has a positive effect on pain reduction, with the greatest effect after 1 month of treatment. The application of this oil improves chewing, swallowing, speech and quality of life and helps this individuals to have better social life.